Abstract
Bimetallic nanoparticles act as a multi-functional platform because of extraordinary properties that are most capable materials for biological applications. The present study reports the improvement of Au@ Ag-core shell nanoparticles filled in as seeds for ceaseless affidavit of silver molecules on its chitosan surface. The FT-IR spectrum techniques used to identify stretching vibrations of prepared NPs. The X-ray diffraction (XRD) outcomes show the medium crystalline shape and size of the Ag@Au loaded chitosan was around at 30 nm. The morphological structure of nanoparticles (NPs) was proved by Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). The Ag@Au contained chitosan results displayed the most elevated zone of hindrance 24 mm and lowest value 0.2 μg/mL of MIC against E. coli and treated with ciprofloxacin. The excellent antimicrobial results proven that the Ag@Au loaded chitosan can enhance the antibacterial activity. The combined Ag@Au core-shell NPs were intricately performed for cytotoxicity against human bosom malignant growth (MCF7) and cervical (HeLa) anticancer cell lines. The Ag@Au NPs may have incredible potential as viable antibacterial operators for pathogen control in clinics and nourishment preparing.
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