Abstract
Coupling of 9-[2-(diisopropyloxyphosphonylmethoxy)ethyl]-6-chloropurine (23) (and (R)-9-[2-(diisopropyloxyphosphonylmethoxy)propyl]-6-chloropurine (24), respectively) with organocuprates derived from Grignard reagents afforded after deprotection 6-(sec- or tert-alkyl) substituted phosphonates 31-36. As a model a series of 6-(sec- or tert-alkyl)purines 2-12 was also prepared.
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