Abstract
AbstractWe developed a very efficient and practical method for the large‐scale synthesis of a trans‐hydrindan derivative related to vitamin D, based on the Criegee rearrangement. This ketone is a valuable synthon for the preparation of Gemini‐type vitamin D analogues or other calcitriol analogues modified at C‐20, C‐21 or the D‐ring. Our methodology is superior to those previously reported when considering efficiency and expediency.
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