Synthesis of a technetium‐99m labelled L‐tyrosine derivative with the fac‐99mTc(I)(CO)3‐core using a simple kit‐procedure

Abstract

AbstractThe synthesis of a novel technetium‐99m labelled derivative of L‐tyrosine as a potential tumour imaging agent for nuclear medicine diagnosis is reported. The synthesis involved the labelling precursor fac‐[99mTc(OH2)(CO)3]+ which was synthesized using the commercially available Isolink®‐labelling kit and the tyrosine derivative O‐(N,N‐bis(carboxymethyl)aminoethyl)‐L‐tyrosine trifluoroacetate. The labelled compound O‐(99mTc(I)‐tricarbonyl‐N,N‐bis(carboxymethyl)aminoethyl)‐L‐tyrosine was obtained in a radiochemical yield of 70–80% within 60 min with a radiochemical purity greater than 98% without any HPLC purification step. Purification was achieved merely by solid phase extraction. Chemical as well as chiral purity was determined using gradient‐ and chiral HPLC. Copyright © 2004 John Wiley & Sons, Ltd.