Synthesis of a series of pyrrole‐1‐acetic acids as potential antiinflammatory agents

Abstract

AbstractA series of 3‐substituted 2‐amino‐4,5‐dimethylpyrrole‐1‐acetic acid derivatives were synthesized. The condensation of acetyl methyl carbinol, ethyl glycinate, and the appropriate acetonitrile yielded ethyl 3‐substituted 2‐amino‐4,5‐dimethylpyrrole‐1‐acetate, which was consequently hydrolyzed to produce the corresponding carboxylic acid. The acetamide and trifluoroacetamide series were synthesized by reacting the ethyl 2‐aminopyrrole‐1‐acetates with acetyl chloride or trifluoroacetic anhydride respectively. The corresponding 2‐acetamidopyrrole‐1‐acetic acids were formed by basic hydrolysis of the ethyl esters.