Abstract
A novel cyclophane (9) having eight carboxyl groups that are attached on the aromatic rings via a spacer (-CH 2 SCH 2 -) was designed and synthesized as a host for cationic, anionic, and neutral aromatic guests in alkaline water. Macrocyclization of 7 with 6 was carried out under high dilution condition to give the objective 8 in 17% yield
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