Synthesis of a novel uridine analogue and its use in attempts to form new cyclonucleosides using ring-closing metathesis

Abstract

One novel nucleoside analogue having a hex-5-enyl group and an allyl group in the 5′-C and 3-N position was synthesized regio- and diastereoselectively from d-glucose in twelve steps. In order to reach a particular conformation of nucleosides the nucleoside formation of restricted cyclonucleoside analogues was studied via Ring-Closing Metathesis.