Abstract
In recent year, metal–organic frameworks (MOFs) have been displayed to be a category of promising drug delivery systems because of their crystalline structure, the potential of further functionality, and high porosity. In this research, graphene oxide was synthesized from pure graphite via hummer method and then MgFe2O4 nanoparticles was incorporated into the synthesized ZIF-8 metal–organic frameworks which followed with loading on the surfaces of graphene oxide. In continue, tetracycline as an antibiotic drug was loaded on the surfaces and the cavities of the prepared nanocomposite. The outcomes of this research revealed that 90% of the tetracycline was loaded on the synthesized ZIF-8/GO/MgFe2O4 nanostructure. Next, drug release was done at pH: 5 and pH: 7.4 within 3 days, resulting about 88% and 92% release of the tetracycline, respectively. With using different spectroscopic methods like X-ray crystallography (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX/Mapping), Fourier transform infrared (FTIR), thermalgravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET), the structure of synthesized materials was confirmed. Furthermore, the antibiotic activity of tetracycline trapped into the ZIF-8/GO/MgFe2O4 was evaluated by agar-well diffusion method on both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria, which showed good antibacterial results.
Highlights
In last decade, more attention has been paid to improvement novel techniques for the advancing of drug delivery systems
EDX analysis has been performed in the mode of elemental mapping of the zeolitic imidazole frameworks (ZIFs)-8/Graphene oxide (GO)/ MgFe2O4/TC nanocomposite (Fig. 6)
The X-ray diffraction (XRD) analysis associated with ZIF-8/MgFe2O4 showed that both of the synthesized materials were crystalline and their shapes is consistently based on single crystal techniques (Fig. 10c)
Summary
More attention has been paid to improvement novel techniques for the advancing of drug delivery systems. In order to drug loading on ZIF-8/GO/ MgFe2O4, 0.05 g of the activated ZIF-8/GO/MgFe2O4 powder was mixed with tetracycline (0.1 g) and ultrapure water (5 mL). The FT-IR spectrum of ZIF-8/GO/MgFe2O4 displays a broad and intense peak at 3367 cm−1 due to stretching vibration of O−H groups in grapheme oxide.
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