Abstract
AbstractA boronated aminocyclobutanecarboxylic acid was synthesized for potential use in neutron capture therapy. The synthesis involves the preparation of hydroxymethylcyclobutanone ketal, which is then converted to an amino acid using Bucherer–Strecker methodology. The molecule is modeled after the unnatural amino acid, 1‐aminocyclobutanecarboxylic acid, which has demonstrated high uptake in brain tumors. Copyright © 2003 John Wiley & Sons, Ltd.
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