Abstract
A new π-extended fluorescent dye, a hybrid of naphthocoumarin and rhodamine (NCR), has been developed by the acid-promoted condensation of 2-(4-diethylamino-2-hydroxy) benzoylbenzoic acid with naphthocoumarin. Compared with those of traditional rhodamine fluorophores, the maximum absorption and emission wavelengths of the π-extended NCR are obviously red-shifted. Based on this dye, we constructed the novel Cu2+-selective fluorescent probe NCR-Cu, demonstrating the value of this functional dye. Via a specific Cu2+-promoted ring-opening and hydrolysis processes, it shows high selectivity and sensitivity for Cu2+ detection with the detection limit down to the 10−8 M range. At the same time, the probe NCR-Cu is living cell membrane permeable and can be utilized as a practical vehicle for visualizing Cu2+ in living cells by fluorescence microscopy.
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