Synthesis of A New Series of N-Substituted-3-Indolyl-Heterocycles for Antimicrobial Evaluation

Abstract

indol-3-yl)-3-phenyl-prop-2-ene-1-ones(2a-e). Cyclocondensation of 2a-e with urea, thiourea or guanidine led to the formation of pyrimidine derivatives 3a-e -5a-e, respectively. Base catalyzed reaction of 2a-e with ethyl acetoacetate gave cyclohexanone derivatives 6a-e, which were reacted with hydrazine hydrate to afford the indazole derivatives 7a-e. On the other hand, reaction of 2a-c with some hydrazine derivatives namely, hydrazine hydrate, acetyl hydrazine, phenyl hydrazine and benzyl hydrazine hydrochloride yielded the pyrazole derivatives 8a-c–11a-c, respectively. Moreover, reaction of 2a-c with hydroxyl amine hydrochloride gave the isoxazole derivatives 12a-c. The newly synthesized compounds were tested for their antimicrobial activity and the results revealed that, 4-(