Abstract
A new series of substituted 8-fluro-4 H-pyrimido[2,1-b] [1,3]benzothiazole-4-ones () substituted 7-methyl-4 H-isoxazolo[2,3- a]pyrimidin-4-ones, and substituted 2-methyl-5,6,7,8-tetrahydro-9 H-isoxazolo[2,3- a]pyridopyrimidin-9-ones, compounds I–VII, have been prepared via condensation of β-keto esters with 2-aminopyridine derivatives, in the presence of polyphosphoric acid. The same technique has also been used to prepare diazepine compounds, VIII– X, by condensation of a γ-keto ester with 2-aminopyridine derivatives. Details of synthetic procedures are shown. The new compounds have been characterized by elemental analysis, GC–MS, FT-IR and NMR spectrometry. Antibacterial, antifungal and anticancer (cytotoxic) activities, for three of these compounds, have been investigated and are presented.
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