Synthesis of a new binuclear silver(I) complex with the ability to interact with DNA molecule

Abstract

A new binuclear silver complex, [Ag2(FcCOO)2(dppm)2].2CH3CN, Fc-COOH = ferrocenecarboxylic acid, dppm = bis(diphenylphosphino)methane, with the ability to form binding with DNA molecule, was synthesized and its structure determined by elemental analysis, FT-IR, 13C NMR, 31P NMR and X-ray crystallography. Considering the potential of the complex A1 in the cancer treatment, the interaction of this complex with calf thymus DNA (CT-DNA) was investigated by using electronic absorption spectra, fluorescence and redox behavior techniques. The experimental results showed that there is an electrostatic interaction between complex and CT-DNA.