Abstract
This article follows on from our previous work in the area of non-viral gene delivery using polycationic dendrimers (PCDs). Herein we report on the synthesis and efficacy of a new library of lipid core PCDs in the delivery of the anti-angiogenic oligonucleotide (ODN-1) to retinal pigment epithelial cells. ELISA was used to monitor hVEGF levels in cells transfected with dendriplexes, Cytofectin GSV™ and control (non-transfected). At 48 h, hVEGF titres had returned to that of the untransfected control for Cytofectin GSV™ however, a number of dendriplexes continued to exhibit a marked reduction in hVEGF titres.
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