Abstract
Disaccharide 4 was designed as a structurally simplified, potential mimic of sialyl Lewis X ( 1). 4 was prepared utilizing Schmidt's trichloroacetimidate methodology in 10 linear steps from methyl galactoside 5. 4 exhibited activity in an E-selectin binding assay at concentrations 40 to 45-fold higher than that observed for monomeric sialyl Lewis X.
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