Abstract
A new fluorescent probe P based on rhodamine for Cu2+ was synthesized and characterized. The new probe P showed high selectivity to Cu2+ over other tested metal ions. With optimal conditions, the proposed probe P worked in a wide linear range of 1.0 × 10−6−1.0 × 10−5 M with a detection limit of 3.3 × 10−7 M Cu2+ in ethanol-water solution (9:1, v:v, 20 mM HEPES, pH 7.0). Furthermore, it has been used for imaging of Cu2+ in living cells with satisfying results.
Highlights
The selective detection of chemical species upon molecular recognition is of great significance in the host environment, when the guest is ionic
Inspired by these research works, we report here a new fluorescent probe P based on a rhodamine B derivative for Cu2+ (Scheme 1)
Nuclear magnetic resonance (NMR) spectra were measured with a Brucker AV 400 instrument, and chemical shifts were given in ppm from tetramethylsilane (TMS)
Summary
The selective detection of chemical species upon molecular recognition is of great significance in the host environment, when the guest is ionic. Even though considerable efforts have been devoted to Sensors 2014, 14 developing fluorescent probes for Cu2+ over the last few decades [7,8,9], it is still of great importance to develop new Cu2+-selective probes. Inspired by these research works, we report here a new fluorescent probe P based on a rhodamine B derivative for Cu2+ (Scheme 1). It showed a reversible “turn-on” fluorescent response for Cu2+ in aqueous solution with remarkably high sensitivity and selectivity.
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