Abstract
Attempted preparation of the immunoadjuvant lipopeptide Pam2CysSKKKKG by Boc SPPS resulted in unexpected cleavage of the palmitoyl esters during HF-mediated cleavage from the resin. An alternative strategy using a combination of a sulfonamide linker, Fmoc SPPS and milder deprotection conditions afford the requisite peptide with the palmitoyl groups intact.
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