Abstract
Antisense and siRNA oligonucleotides have been widely used in the past decade as an efficient gene-silencing tool in molecular biological investigations. However, their therapeutic application has hitherto been hampered by their poor pharmacokinetic properties.
Highlights
Antisense and siRNA oligonucleotides have been widely used in the past decade as an efficient gene-silencing tool in molecular biological investigations
The main focus of this work lies on the synthesis of a modified adenosine nucleoside which is aimed to serve as the joining point of oligopeptide moiety at the 2’-position
The oligonucleotide was afterwards synthesized on a DNA-synthesizer
Summary
Antisense and siRNA oligonucleotides have been widely used in the past decade as an efficient gene-silencing tool in molecular biological investigations. Synthesis of a Building Block for OligopeptideOligonucleotide Conjugates Their therapeutic application has hitherto been hampered by their poor pharmacokinetic properties.
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