Abstract

A novel acromelic acid analogue containing a phenyl group possessing two different types of azido functional groups, of which one is the aromatic N 3 acting as a photoaffinity group to bind to a target protein by photoirradiation and the other is alkyl N 3 group which survives photolysis acting as a detecting group through the Staudinger–Bertozzi reaction to identify the ligated product, was designed and synthesized as a radioisotope-free biochemical probe potentially for studies on kainoid receptors.

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