Abstract
An anti-fungal derivative of rosin, bi-quaternary ammonium salt (B-QAS) was synthesized. First, rosin was modified by acrylic acid. Then using this modified rosin reacted with an intermediate quaternary ammonium (epoxy propyl triethyl ammonium chloride) which was the reaction product of triethylamine and epichlorohydrin. The final product was bisN-(3-rosin acyloxy -2-hydroxy) propyl-N, N triethyl ammonium chloride. The chemical structure of the product and its functional groups was characterized by Fourier transform infrared spectroscopy (FTIR). Its yield of greater than 80% was conformed by high performance liquid chromatography (HPLC) and gravimetric analysis. Its anti-fungal activity was determined in vitro with a paper-disc method. B-QAS presented significant inhibitory effect for Trametes versicolor, Gloeophyllum trabeum and Postia placenta when its concentration was 0.5 mg/mL, whereas for Irpex lacteus the inhibitory effect was a little poor.
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