Abstract
The functional group-containing potassium ionophore 195,245-dibromo-4,7,13,16,20,23-hexaoxa-1,10-diaza-19(1,2),24(1,2)-dibenzabicyclo[8.8.6]tetracosaphane has been synthesized.
Highlights
Potassium (K+) is a major cationic constituent of living cells; its concentration in intercellular living cells is around 150 mmol·dm-3, whilst its extracellular levels are typically around 4 mmol·dm-3.Potassium level measurements of are importance in the fields of cell physiology and clinical medicine [1,2].Fluoroionophores based on a fluorescent coumarin group probe and the ionophore 1,10-diaza-18crown-6 chelating group, which is selective for K+ ions, and capable of measuring K+ in an aqueous physiological environment have been reported [3].Fluoroionophore sensors possess a guest binding site having a heteroatom with nonbonding electron pairs such as nitrogen, and a photon-interaction site capable of accepting electrons
In the absence of a cation that binds selectively in the cavity of ionophore, when the fluorophore is excited by a photon, electron transfer from the ionophore to the fluorophore results in fluorescence quenching
In the presence of a cation which selectively binds to the ionophore and inhibits the electron transfer process, the fluorescence of fluorophore is switched on
Summary
Potassium (K+) is a major cationic constituent of living cells; its concentration in intercellular living cells is around 150 mmol·dm-3, whilst its extracellular levels are typically around 4 mmol·dm-3.Potassium level measurements of are importance in the fields of cell physiology and clinical medicine [1,2].Fluoroionophores based on a fluorescent coumarin group probe and the ionophore 1,10-diaza-18crown-6 chelating group (abbreviated by the acronym CD18), which is selective for K+ ions, and capable of measuring K+ in an aqueous physiological environment have been reported [3].Fluoroionophore sensors possess a guest binding site (ionophore) having a heteroatom with nonbonding electron pairs such as nitrogen, and a photon-interaction site (fluorophore) capable of accepting electrons. Treatment of X with 3,6-dioxaoctanedioyl dichloride afforded XI (195,245-Dibromo-4,7,13,16,20,23hexaoxa-1,10-diaza-19(1,2)24(1,2)-dibenzabicyclo[8.8.6]tetracosaphane-2,9-dione) which upon reduction with borane in THF gave the dibromocryptand VIII.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
