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Abstract
L-683,877, a high affinity, 5-HT 3 selective receptor ligand has been labeled with 11C for use in PET studies to measure regional brain kinetics of L-683,877 and to determine if [ 11C]L-683,877 can be used for serotonin 5-HT 3 receptor imaging. [ 11C]L-683,877 was prepared by reacting [ 11C]methyl iodide with the desmethyl, borane-protected precursor, L-686,472, in DMF in the presence of tetrabutyl ammonium hydroxide. The average specific activity of [ 11C]L-683,877 was 2700 Ci/mmol and the average radiochemical yield (decay uncorrected) was 20% at the end of synthesis (22 min from EOB).
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Schedule a callMore From: International Journal of Radiation Applications & Instrumentation. Part A, Applied Radiation & Isotopes
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