Abstract
Our synthetic strategy was based on the work described by Shih et al. 3 (Scheme 1). Several procedures are described for the preparation of the starting material, 6-methyl-4-pyrimidinone derivatives 1, using guanidine or thiourea, ethyl acetoacetate, with or without base, under reflux of ethanol or methanol for several hours. 4,5 Schmink et al. 6 described recently a MW assisted synthesis of 6methylthiouracil (1b) using KOH in ethanol. We tested the reaction for the preparation of 1a-c with and without base, solvent, under conventional heating and also under MW. The best results were obtained without base and solvent under MW irradiation in 65 and 56% yield, for 1a and 1b, respectively (Scheme 1). 6-Methyluracil (1c) has not been obtained in any experimental condition we have tested.
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