Abstract
Abstractmagnified imageTricyclic dihydropyridines like ZM244085 are potential KATP channel openers. In this study 3‐cyanophenyl ring of ZM244085 was replaced with imidazolyl ring. So, 9‐[1‐benzyl‐5‐(alkylsulfonyl)‐1H‐2‐imidazolyl]perhydro‐1,8‐acridinediones (5d‐f) were synthesized from 2‐alkylsulfonyl‐1‐benzyl‐5‐formylimidazole (4d‐f) and cyclohexane‐1,3‐dione according to classical Hantzch synthesis as potential potassium channel modulators.
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