Abstract
We report herein the synthesis of series of 9-substituted derivatives of tert-butyl 6-(9H-purin-6-ylthio) hexylcarbamate by the reaction of tert-butyl 6-(9H-purin-6-ylthio) hexylcarbamate with different acid chlorides using triethylamine in Dichloromethane solvent.
Highlights
The purine ring system possesses undisputed biological importance and it is considered to be one of the most important heterocyclic rings in nature [1]
De novo purine synthesis and several enzymes involved in the purine metabolism pathway are important targets for antimetabolites [2]
The purine nucleoside analogs are used in the treatment of autoimmune diseases [5]. 6-mercapto purine is used therapeutically as an immunosuppressive agent [6] and inhibits the growth of bacterial and mammalian cells [7]
Summary
The purine ring system possesses undisputed biological importance and it is considered to be one of the most important heterocyclic rings in nature [1]. Tert-butyl 6-(9-(2-trifluoromethylbenzoyl)-9H-purin-6-ylthio) hexylcarbamate 8c: 1H NMR (CDCl3): δ 8.55 (s, 1H), 8.51 (s, 1H), 7.86 (d, J=7.6 Hz, 1H), 7.79-7.70 (m, 2H), 7.52 (d, J=7.6 Hz, 1H), 4.49 (br s, 1H), 3.35 (t, J=7.2Hz, 2H), 3.11-3.09 (m, 2H), 1.81-1.73 (m, 2H), 1.561.36 (m, 6H), 1.43 (s, 9H); IR (KBr, cm-1): 3392, 2932, 2860, 1719, 1569, 1368, 1316, 1170, 1138, 900, 771, 634; Anal.
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