Abstract
8-(2-fluoro-4-nitrophenoxy)-[1,2,4] triazolo [4,3-a] pyrazine (1) is an important intermediate in many biologically active compounds. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available 2,3-dichloropyrazine (5) through three steps including substitution reaction and ring buckling reaction. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 80.04%.
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