Abstract
Abstracto‐Aminoamide 8, an intermediate in our multistep synthesisof the title compounds was prepared from 1,3‐diketone 3. The following condensation of 8 with chloroformamidine‐HCl (9) gave pyrido[3,4‐d]pyrimidine 10. Dehydratisation of amide 8 led to o‐aminonitrile 15, which was cyclocondensated with guanidine (16) to yield pyrido[3,4‐d]pyrimidine‐2,4‐diamine 17. Coupling of the acids 11 and 18 with diethyl L‐glutamate (12) and following saponification provided 7‐aza‐5,8,10‐trideazafolic acid 14 and its 4‐amino‐derivative 20.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
