Abstract
The regio- and stereoselectivity of the addition reactions of O-, C-, N-, and S-nucleophiles to 6-deoxy-d,l-iminoallal- and -d,l-iminogalactal-derived epoxides 2α and 2β was examined. Results indicated that the 1,4-/1,2-regioselectivity ratio and the related syn-1,4-/anti-1,2-stereoselectivity is closely and directly dependent on the ability of the nucleophile to coordinate with the oxirane oxygen and the configuration of the epoxide. A formal synthesis of a 1,6-dideoxy-piperidine azasugar is also described.
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