Abstract
A novel bifunctional chelator combines a dithiocarbamate group for binding the positron-emitter 64Cu (red spheres) for PET imaging and a bisphosphonate group (green ellipsoids) for strong binding to several inorganic materials, such as MRI contrast agents based on superparamagnetic iron oxide nanoparticles and rare-earth metal oxides. The dual PET–MR imaging capabilities of this approach are demonstrated in vivo by imaging lymph nodes using both imaging modalities.
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