Abstract
2-Alkyl-3-hydroxy-4(1 H)-pyridinones can be oxidized by silver(I) oxide in alcoholic solution to give 2-alkoxy-2-alkyl-1,2dihydro-pyridine-3,4-diones, which can subsequently undergo a Michael addition with nucleophiles to give 6-substituted-2-alkyl-3-hydroxy-4(1 H)-pyridinones.
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