Abstract
The regioselective radiofluorodestannylation of 6-trimethylstannyl- l- m-tyrosine derivative 6 with [ 18F]F 2 and [ 18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[ 18F]fluoro- l- m-tyrosine ( 8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[ 18F]fluoro- l- m-tyrosine ( 13a) was synthesized in 11% radiochemical yield from the corresponding 4-trimethylstannyl- l- m-tyrosine derivative 11 using [ 18F]F 2. The structural analyses of precursors ( 6, 11), intermediates, and the final products (after 18F decay), were carried out by 1H, 13C, 19F, 119Sn-NMR and high resolution mass spectroscopy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
