Abstract
The first hydroxamate-based and potent transition state analogue (TSA) inhibitor of 6-phosphate-D-glucose isomerases, 5-phosphate-D-arabinohydroxamic acid 3, has been synthesized by conversion of D-arabinose to a protected derivative of 5-phosphate-D-arabinonic acid and introduction of the hydroxamate group by coupling with O-benzylhydroxylamine.
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