Synthesis of 5-arylazothiazoles, pyridines and thieno[2,3-b]pyridines derivatives containing 1,2,3-triazole moiety

Abstract

1-(2-(4,5-dihydro-3-(5-methyl-1-phenyl-1 H -1,2,3-triazol-4-yl)-5-phenylpyrazol-1-yl)-4-subs-tituted-thiazol-5-yl)-2-phenyldiazene ( 4 ) and substituted pyridines ( 5 - 12 ) were synthesized via reaction of 1-(5-methyl-1-phenyl-1 H -1,2,3-triazol-4-yl)-3-phenylprop-2-en-1-one with hydrazonoyl halides and active methylene compounds. Also, thieno[2,3- b ]pyridines ( 14a - e ) were prepared through reactions of 2-mercapto-6-(5-methyl-1-phenyl-1 H -1,2,3-triazol-4-yl)-4-phenyl-pyridine-3-carbonitrile with halo ester and halo ketones, respectively. The newly synthesized derivetived were elucidated by elemental analysis, spectral data and alternative synthetic routes wherever possobile.