Abstract
Pyrimidine-2,4,6(1H,3H,5H)-trione (barbituric acid) 1 due to the high mobility of methylene hydrogen atoms in the pyrimidine ring is known to be nitrated to 5,5-dinitrobarbituric acid and nitrosated to violuric acid [1]. Compound 1 as well as its 2-thioand 2selenoanalogs enter in the condensation with aromatic aldehydes and dialdehydes (terephthalic aldehyde), and also with heterocyclic aldehydes (2-furaldehyde, 5aryl-2-thiophenecarbaldehydes) or with diketone (6,6dimethyl-1-phenyl-6,7-dihydro-1Н-indazole-4,5-dione) to form the corresponding 5-arylmethylidene(hetarylmethylidene) derivatives [2–6]. The formation of analogous products is also the result of the reaction of pyrimidine-2,4,6(1H,3H,5H)-trione or its 2-thioanalog with 2-monosubstituted or 2,6-disubstituted γ-pyrones and 4-pyridones [7, 8].
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