Abstract
Main observation and conclusion1,3‐Butadiene plays a key role in modern synthetic chemistry and biochemistry because it is a key intermediate in the synthesis of many drugs. A new and effective method for the synthesis of 4‐trifluoromethylated 1,3‐butadiene through the fluorinated Heck reaction catalyzed by Pd(0) is described. Without additives, 1‐chloro‐3,3,3‐trifluoropropene (an inexpensive CF3 structural unit that is harmless to ozone) reacts with enamide to synthesize 4‐trifluoromethylated 1,3‐butadienes with good yield, high regioselectivity and chemical selectivity, and strong tolerance of substrate functional groups such as alkynes, aldehyde, and ester groups.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
