Abstract
The chiral ligand (−)-(4 R,5 R)-4,5-bis[di-3′-(2′,6′-dimethoxypyridyl)phosphinomethyl]-2,2-dimethyl-1,3-dioxolane 3 [( R,R)-Py*-DIOP] was synthesized via a key intermediate bis[3-(2,6-dimethoxypyridyl)]phosphine-borane 9. The asymmetric hydrogenation of prochiral olefins was investigated using a rhodium catalyst containing 3. For the hydrogenation of amidoacrylic acids, enols and itaconic acid, while the enantioselectivity of [Rh-( R,R)-Py*-DIOP] was similar to that of [Rh-( R,R)-DIOP] the absolute configurations of the products from the two catalyst systems were found to be opposite.
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