Abstract
An alternative method for the synthesis of 4-alkyl-2 (5H)-furanones is described. Intramolecular carbene addition reaction of α-diazo compounds (4) in the presence of rhodium acetate or copper acetylacetonate furnished the bicyclic compounds (5), which were subjected to cyclopropane ring-opening reaction to give the 4-alkyl-4, 5-dihydrofuran-2 (3H)-ones (6) regioselectively. These compounds (6) were further converted into 4-alkyl-2 (5H)-furanones (14) in several steps.
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