Abstract
Claisen–Schmidt-type aldol-crotonic condensation of 3-acetyl-5-nitropyridine derivatives with various aromatic aldehydes was used for the preparation of pyridylchalcones. Cyclization of the latter with hydrazine hydrate in acetic acid afforded the corresponding N-acetyl derivatives of 4,5-dihydro-1H-pyrazole.
Highlights
Chalcones are of important practical interest to chemists due to their availability and pronounced pharmacological activity of natural chalcones and their synthetic analogues
Claisen-Schmidt-type aldol-crotonic condensation of 3-acetyl-5-nitropyridine derivatives with various aromatic aldehydes was used for the preparation of pyridylchalcones
Due to poor solubility in a water-alcohol medium, the starting 5-nitropyridines were pre-dissolved in a minimum amount of methylene chloride (Scheme 2)
Summary
Chalcones are of important practical interest to chemists due to their availability and pronounced pharmacological activity of natural chalcones and their synthetic analogues.
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