Synthesis of 4-(2-Chloropropyl)-2-Methoxyphenol from Eugenol and Ketoprofen by Hydrohalogenation Reaction using HCl Catalyst

Abstract

Eugenol is a phenolic compound that has hydroxy and allyl groups in its structure. Eugenol can be transformed into its derivative through esterification and addition reactions. Esters can be synthesized through Fischer esterification reactions using concentrated HCl as catalyst. The use of HCl as catalyst in esterification of eugenol may form 4-(2-chloropropyl)-2-methoxyphenol from hydrohalogenation reaction between the allyl eugenol and HCl. The purpose of this study was to determine the formation of a 4-(2-chloropropyl) 2-methoxyphenol compound as a result of hydrohalogenation reaction eugenol and ketoprofen using HCl as catalyst and to find out the identification of the compound. The results showed that synthesis of 4-(2-chloropropyl)-2-methoxyphenol compound as eugenol derivative was formed by hydrohalogenation reactions. The compound was identified based on the results of the analysis using FTIR, GC-MS, and HPLC instruments.