Abstract
The synthesis of two new dopamine transporter ligands, 3β-(4-fluoromethylphenyl)tropane-2β-carboxylic acid methyl ester and 3β-(2-fluoromethylphenyl)tropane-2β-carboxylic acid methyl ester, and their spectral characterization are described. The precursors for these ligands were prepared by TiCl 4 catalyzed chloromethylation of 3β-phenyltropane-2β-carboxylic acid methyl ester followed by separation of the isomeric product mixture of 2- and 4-chloromethylphenyltropane derivatives. Reaction of the chloromethyl analogs with no-carrier-added [ 18F]fluoride ion followed by high performance liquid chromatography purification provided the corresponding [ 18F]fluoromethyltropanes, in good radiochemical yields, useful for imaging the brain dopamine transporter system in vivo with positron emission tomography.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
