Abstract
3-Trimethylsilyloxy-1-(furan-3-yl)butadiene was synthesized and studied in reactions with 2,2-dimethyl-5-methylidene-1,3-dioxane-4,6-diones, 5-methylenepyrimidine-2,4,6-triones, as well as with imines. Reactions with dienophiles containing an exo-methylene double bond in the presence of L-proline occurred regio- and stereoselectively with the formation of 7-(furan-3-yl)spiro[5,5]undecane-1,5,9-triones or 7-(furan-3-yl)-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraones. The reaction of diene with methylene imine, obtained from L-phenylalanine methyl ester and formaldehyde, in the presence of Lewis acids led to the formation of 2-(furan-3-yl)piperidin-4-one or the product of ene reaction, methyl (2S)-2-{[(4E)-5-(furan-3-yl)-3-oxopent-4-en-1-yl]amino}-3-phenylpropanoate. The structures of three compounds were confirmed by X-ray structural analysis.
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