Synthesis of 3-substituted carboxylate/carboxamide flavone derivatives from 4-hydroxycoumarin, β-nitrostyrene and alcohol/amine using multicomponent reaction

Abstract

A wide range of 3-substituted carboxylate/carboxamide flavone derivatives were synthesized from 4-hydroxycoumarin, β-nitrostyrene and alcohol/amine using multicomponent reaction in the presence of N,N-dimethyl-4-aminopyridine (DMAP). Good yield, short reaction time, atom economy, cost effectiveness, and use of non-toxic organo-catalyst are some of the remarkable advantages of the present protocol.