Abstract

The amination of 3-(2′-oxocyclohexyl)methylcaprolactams and -valerolactams with ammonium acetate leads to 3-(ω-aminoalkyl)-3,4,5,6,7,8-hexahydro-2-quinolones. The hydroamination of these keto lactams, as well as their oxocycloheptyl analogs, with a mixture of formamide and formic acid gives 3-(ω-aminoalkyl)peŕhydro-2-quinolones and 3-(ω-aminoalkyl)-5,6-pentamethylenetetrahydro-2-pyridones.

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