Abstract
4-[2-(Difluoromethoxy)phenyl]-substituted 3-alkoxycarbonyl-6-alkylsulfanyl-3-cyano-2-methyl-1,4-di-hydropyridines and related pyridine and 4,7-dihydrothieno[2,3-b]pyridine derivatives have been prepared, their memory-improving activity has been studied using the passive avoidance responses in the acquisition test, and their calcium overload-preventing activity in SH-SY5Y neuroblastoma cell line in the presence of the agonist carbachol has been examined. 1,4-Dihydropyridine derivatives bearing the 2-propoxyethoxycarbonyl group in position 3 and having weak influence on calcium overload in neuronal cells show high activity comparable with that of cerebrocrast.
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