Abstract

AbstractNew 3‐acylamino‐2‐oxazolidinone derivatives 3 were obtained in good yields by reaction of 5‐aryl (or benzyl)3‐(2‐hydroxyethyl)1,3,4‐oxadiazol‐2(3H)ones 1 with sodium ethylate. Treatment of ethyl 5‐aryl‐2‐oxo‐1,3,4‐oxadiazole‐3(2H)‐acetates 7 with aromatic aldehydes in the presence of sodium ethylate or sodium hydride afforded 3‐acylamino‐5‐aryl‐4‐ethoxycarbonyl‐2‐oxazolidinone derivatives as two trans‐5 and cis‐6 racemics. Only RS,SR‐racemates were obtained with acetophenone under the same conditions.

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