Abstract
Reaction of 3, 6-diethoxycarbonyl-1, 4-dimethyl-2, 5-piperazinedione (15), prepared by heating of diethyl methylaminomalonate (14), with NaH in dioxane and followed treatment with S2Cl2 gave 3, 6-epidithio- and 3, 6-epitetrathio-3, 6-diethoxycarbonyl-1, 4-dimethyl-2, 5-piperazinediones (16b and 16d), which have the skeletone (1) observed in fungal metabolites such as sporidesmin. The reduction of 16 with NaBH4 in methanol gave the dethio derivative (15) in good yield. The reaction of 16d with triphenylphosphine in tetrahydrofurane gave 16c and 16b. The reaction of diethyl malonate derivatives (23a, b, and c) with NaH and S2Cl2 in dioxane gave the corresponding disulfides or trisulfides (24a, b, and c). Some reactions of proline anhydride (5) and sarcosine anhydride (7) with S2Cl2 or sulfur were examined.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
