Synthesis of 3, 5-Disubstituted-Tetrahydro-2h-1, 3, 5-Thiadiazine2-Thiones Derivatives and their Metal Complexes as Potential Bioactive Agents

Abstract

Thiadiazine thione derivatives (2-(5-(2-.hydroxyethyl)-2-thioxo-1,3,5-thiadiazinane-3-yl) Acetic acid, 2-(5-.butyl-6-thioxo.-1, 3, 5-thiadiazinane-3-yl) Acetic acid, 2, 1 and 2 were synthesized by the reaction of alkyl primary amines (glycine, butylamine) with carbon disulfide and potassium hydroxide followed by addition of formaldehyde and various primary amines (ethanolamine, glycine) in phosphate buffer medium. The synthesized compounds were transformed into organometallic complexes (3-12) Ni (II), Co (II), Cu (II), Zn (II) and Fe (II) using their metal salts. The structure determinations of these compounds were elucidated by spectral methods such as IR, NMR spectroscopy and Mass spectrometry. All the synthesized compounds were screened for their anti-microbia++l activities. Their structure activity relationship showed that the potential of tested compounds enhanced with metal complexes against evaluated activities.