Synthesis of 2-substituted benzofuran derivatives by the palladium-catalyzed intermolecular coupling of 2-fluoroallylic acetates with phenols

Takumi Udagawa,Masaki Kogawa,Yukiko Tsuchi,Hirotaka Watanabe,Mitsuaki Yamamoto,Motoi Kawatsura

doi:10.1016/j.tetlet.2016.12.011

Synthesis of 2-substituted benzofuran derivatives by the palladium-catalyzed intermolecular coupling of 2-fluoroallylic acetates with phenols

Takumi Udagawa, Masaki Kogawa + Show 4 more

https://doi.org/10.1016/j.tetlet.2016.12.011

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Journal: Tetrahedron Letters	Publication Date: Dec 7, 2016
Citations: 14

Affiliation: Nihon University

#Intermolecular Cyclization #2-substituted Derivatives + Show 8 more

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Abstract

We investigated the intermolecular coupling reaction of 2-fluoroallylic acetates with simple phenols by the [Pd(C3H5)Cl]2, DPPF, and KHMDS at 100°C for 16h, and succeeded in obtaining 2-substituted benzofuran derivatives in good to high yield through the C–F bond activation and intermolecular cyclization.

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