Abstract
Radiolabeled acetates have potential use in tumor imaging. Moreover, aryl fatty acid displays antitumor effect with phenylacetate currently in clinical trial. A series of 2-R1-2-(4-(2-fluoroethoxy)benzamido)acetate were synthesized in the present investigation. 2-(4-(2-[18F]fluoroethoxy)benzamido)acetate ([18F]FEBA) was evaluated in tumor-bearing mice. It was compared with 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG), showing satisfied stability. Excitingly, the radiochemical purity of [18F]FEBA was more than 99% and the radiochemical yield was up to 25%. Although 2-R1-2-(4-(2-fluoroethoxy)benzamido)acetate deserved further evaluations, the results might provide many experimental foundations and principles for the future study of the novel fluorine-18-labeled pharmaceuticals.
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