Abstract
The synthesis of substituted pyridines has drawn the attention of many chemists due to their importance as building blocks for biologically active compounds and materials. This mini-review focuses on recent developments relating to the synthesis of substituted pyridines from pyridine N-oxides, along with their interesting mechanism aspects. New developments including alkenylation, alkynylation, alkylation, arylation, amination and cyanation are discussed.
Highlights
Substituted pyridines are an important class of compounds in organic synthesis.[1]
Pyridine N-oxides have drawn the attention of numerous research groups, and the number of new synthetic methodologies and modifications of traditional procedures has grown markedly, which has been reflected in the number of research publications in the literature
This mini-review focuses on recent developments relating to the synthesis of substituted pyridines from pyridine N-oxides along with their interesting mechanism aspects
Summary
Substituted pyridines are an important class of compounds in organic synthesis.[1]. The structural framework of substituted pyridines is often seen in natural products, compounds possessing important biological activities, and functional materials.[2]. Pyridine N-oxides have drawn the attention of numerous research groups, and the number of new synthetic methodologies and modifications of traditional procedures has grown markedly, which has been reflected in the number of research publications in the literature. This mini-review focuses on recent developments relating to the synthesis of substituted pyridines from pyridine N-oxides along with their interesting mechanism aspects. We discuss only the most essential reactions here and summarize the recent contributions reported after 2002
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